Fentanyl and opioids have taken many lives and touched many more in the past decades. In middle Missouri, the problem has been no different. Reducing the burden of overdoses in our communities takes collaboration from multiple sectors along with focused educational interventions, harm reduction, and primary prevention. In this presentation, Health Program Coordinators from Columbia/Boone County Public Health and Human Services will discuss their strategies and lessons learned from years of addressing substance use, overdose prevention, and community outreach.